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KMID : 1123920060200041014
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 4 p.1014 ~ p.1020
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Effects of Electro-acupuncture and Therapeutic Exercise on Nervous system in the Ischemic Stroke Rats
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Yoo Young-Dae
Kim Gi-Do
Chun Jin-Sung
Kim Gye-Yeop
Jung Hyun-Woo
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Abstract
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This study was intended to examine the effects of electroacupuncture(EA) and therapeutic exercise on the improvement of exercise function, BNDF, and HSP70 protein expression in an ischemic stroke model induced by MCA occlusion. Experiments were conducted for 1, 3 days, 1, 8 weeks respectively. Group I was a group of EA and therapeutic exercise; Group II was a group of therapeutic exercise; Group III was a group of EA; Group IV was a sham group of EA; Group V was a control group; and Group VI was a sham group without ischemic stroke. In each group, neurologic motor behavior test, histologic observations, BDNF, and HSP70 expression were observed and analyzed. The following results were obtained. The results of behavior test suggest that 8 weeks after ischemic stroke was induced, Group I improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group VI. In immunohistochemical observations, Group I showed increase in BDNF and decrease in HSP70. Based on these results, EA and therapeutic exercise may improve muscle atrophy and change in BDNF and HSP70 expression of ischemic stroke rats and contribute to the improvement of exercise function.
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KEYWORD
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Electroacupuncture, Middle cerebral artery occlusion, BDNF, HSP70
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